No insider purchase over the last 90 days. The latest was filed 19 May 2025.
Syndax Pharmaceuticals Inc is a Healthcare & Pharma company. Its directors and officers file their transactions with SEC (Form 4). 11 insiders have disclosed 21 filings since 18 October 2025.
No insider bought on the market over the period, while 3 insiders filed 5 sales totalling €1.1M. The totals do not cover 2 filings with an undisclosed amount. Biggest ticket of the year: €688k, sold by Metzger Michael A and made public on 9 July 2026 (0.050% of market cap).
Filings reach the SEC (Form 4) feed a median of 2 days after the trade. For comparison, the SEC allows two business days to file a Form 4. A sale on its own says little: insiders also sell to pay tax, fund a purchase or diversify.
For context, the typical company on the same exchange (median of 5,458 companies) published 22 filings over the same period, against 21 filings here. Our records for Syndax Pharmaceuticals Inc go back to 2021, with 5 purchases and 12 sales on the open market in total. For the fiscal year to 31 December 2025, the annual 10-K puts revenue at 172.4 m USD and net income at -285.4 m USD.
Elsewhere in the same sector, our signals recently picked up insider purchases at Anixa Biosciences Inc and Vivos Inc. Source: insider filings from SEC (Form 4). Past trades are no guide to future returns.
Entry is the close on the day after publication, the first price a reader could act on. Prices in the listing currency. Past moves are not a forecast.
Analysts rate Syndax Pharmaceuticals Inc Strong Buy (bullish), based on 11 analysts. Average price target: US$37.27.
This score ranks the purchase within its own market. A position size is suggested only on the venues of the backtested strategy universe; elsewhere, signals stay on watch. Not investment advice.
Transparent value + quality ranking, distinct from the insider signal.
FY ended December 2025 · cache
25 of 115 declarations
Syndax Pharmaceuticals Inc. is a U.S.-based biopharmaceutical company listed on the Nasdaq under the ticker SNDX, trading on the United States equity market. For French-speaking investors, Syndax is best viewed as a commercial-stage oncology specialist rather than a pure early-stage biotech. The company focuses on innovative therapies for hematologic cancers and related indications, and it now has two FDA-approved medicines alongside a broader clinical pipeline designed to expand the addressable market for those assets. Its principal office is in New York, after the company closed its Waltham, Massachusetts office in early 2025. Syndax was incorporated in Delaware in 2005, giving it a meaningful operating history even though its transition into a commercial company is relatively recent.
The investment case is anchored by two lead products. Revuforj (revumenib) is an oral, first-in-class menin inhibitor. It received FDA approval in November 2024 for relapsed or refractory acute leukemia with a KMT2A translocation, and in October 2025 the FDA approved it for another AML population with a susceptible NPM1 mutation. This second approval materially broadens the commercial and clinical opportunity. Niktimvo (axatilimab-csfr), developed with Incyte, is another approved therapy used in chronic graft-versus-host disease (GVHD). Together, these products move Syndax from a development story to a company with real commercial execution risk and upside, as value creation increasingly depends on prescription uptake, launch quality, label expansion, and sustained evidence generation.
Competitively, Syndax remains a niche player versus large pharmaceutical companies, but it has a differentiated scientific profile in hematology-oncology. Its positioning is supported by targeted mechanisms, regulatory designations, and a meaningful development program around expanding approved uses. From a geographic standpoint, commercial activity is primarily U.S.-centered, while the clinical and scientific footprint is international through major hematology and oncology congresses.
Recent developments are especially important. In 2025, Syndax presented multiple clinical datasets for Revuforj and Niktimvo, secured FDA Priority Review for a Revuforj supplemental filing, and then achieved the October 2025 FDA approval that expanded Revuforj into a second AML patient population. The company also reported accelerating commercial revenue in 2025, underscoring the transition from pipeline optionality to launch execution. For investors, Syndax is a high-growth oncology name where commercial traction, regulatory follow-through, and future indication expansion are the key catalysts.
Purchases our model currently ranks for the recommendations list.
All recommendations| Fiscal year end | Revenue | Net income | Diluted EPS | Filing |
|---|---|---|---|---|
| Dec 2025 | 172.4 m USD | -285.4 m USD | -3.29 USD | 10-K |
| Dec 2024 | 23.7 m USD | -318.8 m USD | -3.72 USD | 10-K |
| Dec 2023 | n.d. | -209.4 m USD | -2.98 USD | 10-K |
| Dec 2022 | n.d. | -149.3 m USD | -2.46 USD | 10-K |
| Dec 2021 | 139.7 m USD | 24.9 m USD | 0.46 USD | 10-K |
Amounts in USD, as filed (forms 10-K, 20-F or 40-F). Source: SEC EDGAR.