Karyopharm Therapeutics Inc. Stock: price and directors' dealings · United States · SEC (Form 4)Track the Karyopharm Therapeutics Inc. share price and the full insider trade history of the company, a listed equity based in United States. Shares are quoted on the US market, under the authority of SEC (Form 4). Operating in the Healthcare & Pharma sector, Karyopharm Therapeutics Inc. has logged 177 public disclosures. Market capitalisation: €155.5m. The latest transaction was filed on 30 July 2026 (Cession). Among the most active insiders: Paulson Richard A.. Every trade is openly available.
Analyst consensus: bullish or bearish? Analysts rate Karyopharm Therapeutics Inc. Strong Buy (bullish), based on 5 analysts. Average price target: US$14.80.
This score ranks the purchase within its own market. No market currently meets the historical allocation criteria, so signals remain watch-only. Not investment advice.
Σ Sigma AI Analysis Fundamental view, insider signal, bull and bear case, synthesis.
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Last declaration on 30 July 2026
All Executives177 Thresholds0 Prospectus0 Other0
Declarations 177 total
▼ EVP, Chief Development Officer · Executives · 28 Jul 2026
189 shares @ US$7.10 Common Stock SEC:0001193125-26-326290:0
◆ Director · Executives · 21 May 2026
15,508 shares 0Common Stock SEC:0001254705-26-000008:0
▼ EVP & Chief Commercial Officer · Executives · 14 May 2026
324 shares @ US$9.50 0.0015% mcap 16.4% of flow Common Stock SEC:0001193125-26-226652:1
▼ Chief Accounting Officer · Executives · 14 May 2026
53 shares @ US$9.50 0.0002% mcap 100.0% of flow Common Stock SEC:0001193125-26-226616:1
◆ EVP, CLO&Secretary · Executives · 13 May 2026
700 shares 0Common Stock SEC:0001193125-26-226604:0
◆ EVP, Chief Development Officer · Executives · 13 May 2026
896 shares 0Common Stock SEC:0001193125-26-226697:0
◆ EVP & Chief Commercial Officer · Executives · 13 May 2026
947 shares 0Common Stock SEC:0001193125-26-226652:0
◆ President and CEO · Executives · 13 May 2026
4,920 shares 0Common Stock SEC:0001193125-26-226613:0
◆ EVP & Chief Medical Officer · Executives · 13 May 2026
947 shares 0Common Stock SEC:0001193125-26-226685:0
◆ Chief Accounting Officer · Executives · 13 May 2026
121 shares 0Common Stock SEC:0001193125-26-226616:0
▼ EVP & Chief Medical Officer · Executives · 21 Apr 2026
449 shares @ US$8.94 0.0018% mcap 6.6% of flow Common Stock SEC:0001825322-26-000006:0
▼ Chief Accounting Officer · Executives · 2 Mar 2026
559 shares @ US$9.4095 35.4% of flow Common Stock SEC:0002045943-26-000003:0
▼ EVP, Chief Development Officer · Executives · 2 Mar 2026
5,101 shares @ US$9.4095 34.6% of flow Common Stock SEC:0001942597-26-000003:0
▼ EVP & Chief Commercial Officer · Executives · 2 Mar 2026
4,604 shares @ US$9.4095 36.6% of flow Common Stock SEC:0001865796-26-000003:0
▼ EVP, CLO&Secretary · Executives · 2 Mar 2026
3,526 shares @ US$9.4095 39.9% of flow Common Stock SEC:0001837741-26-000003:0
▼ EVP & Chief Medical Officer · Executives · 2 Mar 2026
5,066 shares @ US$9.4095 43.8% of flow Common Stock SEC:0001825322-26-000003:0
▼ President and CEO · Executives · 2 Mar 2026
12,361 shares @ US$9.4095 20.2% of flow Common Stock SEC:0001804460-26-000003:0
▼ EVP, Chief Development Officer · Executives · 17 Feb 2026
378 shares @ US$8.63 2.3% of flow Common Stock SEC:0001193125-26-059332:0
◆ President and CEO · Executives · 5 Feb 2026
81,060 shares 0Common Stock SEC:0001193125-26-042799:0
▼ EVP, CFO & Treasurer · Executives · 3 Feb 2026
1,626 shares @ US$6.30 100.0% of flow Common Stock SEC:0001193125-26-037584:0
◆ EVP & Chief Commercial Officer · Executives · 31 Jan 2026
32,415 shares 0Common Stock SEC:0001193125-26-035687:0
◆ EVP & Chief Medical Officer · Executives · 31 Jan 2026
32,415 shares 0Common Stock SEC:0001193125-26-035682:0
◆ EVP, CFO & Treasurer · Executives · 31 Jan 2026
32,415 shares 0Common Stock SEC:0001193125-26-035663:0
◆ EVP, CLO&Secretary · Executives · 31 Jan 2026
32,415 shares 0Common Stock SEC:0001193125-26-035661:0
◆ EVP, Chief Development Officer · Executives · 31 Jan 2026
32,415 shares 0Common Stock SEC:0001193125-26-035655:0
25 of 177 declarations
Load more (152 remaining) 关于 Karyopharm Therapeutics Inc. Karyopharm Therapeutics Inc. 是一家美国生物制药公司,在纳斯达克(美国)上市,总部位于马萨诸塞州牛顿市。公司成立于 2008 年,其科学定位围绕核出口抑制展开,这是一种差异化机制,旨在破坏癌细胞的存活和增殖。Karyopharm 现已成为商业化阶段的组织,具有国际足迹,包括在德国和以色列的业务,同时其运营中心仍位于美国。([karyopharm.com](https://www.karyopharm.com/about/company-overview/?utm_source=openai))
公司业务以其旗舰口服肿瘤疗法 XPOVIO®(塞林克索)为支撑。XPOVIO 已获得美国食品药品监督管理局批准用于多种血液系统恶性肿瘤,包括多发性骨髓瘤,是 Karyopharm 的主要商业资产和收入驱动力。除了这款已上市产品外,公司还在推进针对高未满足需求肿瘤适应症的临床管线,有多个在研药物候选物。Karyopharm 表示拥有一款获批产品和多个临床阶段项目,强调了一种结合商业执行与后期管线选择权的商业模式。([fda.gov](https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-selinexor-refractory-or-relapsed-multiple-myeloma?utm_source=openai))
从竞争角度看,Karyopharm 在竞争激烈的肿瘤学市场中与大型制药公司和专业生物技术同行竞争。其优势在于其 XPO1 生物学和针对难以治疗的癌症的专注战略,这些癌症的治疗选择仍然有限。如果临床数据能转化为有意义的疗效和耐受性优势,这种利基定位可能很有吸引力,但也使公司面临监管风险、竞争压力和小市值生物技术公司典型的融资需求。([karyopharm.com](https://www.karyopharm.com/about/?utm_source=openai))
最近的发展对投资案例尤为重要。在 2025 年末和 2026 年初,Karyopharm 强调其 SENTRY 第 3 期试验在骨髓纤维化中的顶线数据预计将在 2026 年 3 月公布,而第 3 期子宫内膜癌研究的顶线结果仍按计划在 2026 年中期发布。公司还报告称 2025 年收入主要由美国 XPOVIO 净产品销售驱动,并讨论了成本削减行动、流动性管理和最近的融资活动。对于法语使用者投资者,Karyopharm 应被视为一家纳斯达克上市的美国肿瘤学公司,具有集中的商业基础、临床驱动的近期催化剂日程表,以及对 2026 年试验结果的显著上行或下行敏感性。([investors.karyopharm.com](https://investors.karyopharm.com/2026-02-12-Karyopharm-Reports-Fourth-Quarter-and-Full-Year-2025-Financial-Results-and-Highlights-Recent-Company-Progress?utm_source=openai))