No insider purchase over the last 90 days. The latest, by Mehra Anand, was filed 20 Nov 2024.
Every trade that managers of Aclaris Therapeutics, Inc. disclose to SEC (Form 4) is tracked on this page. The company sits in the Healthcare & Pharma sector. The last twelve months, up to 22 October 2026, brought 40 filings signed by 13 insiders.
Only sales appear on the open market, 1 sale in all totalling €1.2M, filed by 1 insider. Biggest ticket of the year: €1.2M, sold by Leonard Braden Michael and made public on 27 April 2026 (0.17% of market cap).
Across the 3,171 companies tracked on its exchange, the median is 24 filings; at 40 filings, this issuer sits above that mark. Looking back to 2016, when coverage begins, insiders filed 46 purchases and 117 sales. The 10-K for the year ended 31 December 2025 shows 7.8 m USD of revenue and -64.9 m USD of net income.
Filings reach the SEC (Form 4) feed a median of 3 days after the trade. US insiders must file a Form 4 within two business days of a trade. Selling is not necessarily a view on the stock: liquidity needs and diversification are common motives.
These figures are compiled from regulatory filings published by SEC (Form 4). They describe what insiders did and are not a recommendation.
Entry is the close on the day after publication, the first price a reader could act on. Prices in the listing currency. Past moves are not a forecast.
Analysts rate Aclaris Therapeutics, Inc. Strong Buy (bullish), based on 11 analysts. Average price target: US$10.18.
This score ranks the purchase within its own market. A position size is suggested only on the venues of the backtested strategy universe; elsewhere, signals stay on watch. Not investment advice.
Transparent value + quality ranking, distinct from the insider signal.
FY ended December 2025 · cache
25 of 568 declarations
Aclaris Therapeutics, Inc. is a U.S.-listed biopharmaceutical company traded on the NASDAQ in the United States, with headquarters in Wayne, Pennsylvania. The company has evolved from a dermatology-focused specialty biotech into a clinical-stage developer of immuno-inflammatory therapies. For investors, ACRS is best viewed as a small-cap biotech with a high-risk/high-upside profile, where valuation is primarily driven by clinical execution, pipeline breadth, and capital discipline rather than current commercial sales. ([investor.aclaristx.com](https://investor.aclaristx.com/news-releases/news-release-details/aclaris-therapeutics-reports-fourth-quarter-and-full-year-2025))
Aclaris’ core business is built around internal drug discovery and early development, with particular expertise in kinase inhibition and immune-inflammatory biology. The company highlights its proprietary KINect platform and a pipeline that spans both small molecules and biologics. It also operates Confluence Discovery Technologies, a full-service discovery and early-development CRO, which supports external research relationships and broadens the company’s scientific capabilities. This structure gives Aclaris both a pipeline engine and a research-services component, although the investment case remains overwhelmingly centered on drug development outcomes. ([aclaristx.com](https://www.aclaristx.com/overview/?utm_source=openai))
The most visible asset is ATI-052, a novel anti-TSLP/IL-4Rα bispecific antibody that the company describes as potentially first-in-class. In 2026, Aclaris reported positive interim Phase 1a results and advanced into Phase 1b proof-of-concept studies in atopic dermatitis and asthma. The company expects top-line readouts from both Phase 1b studies in the second half of 2026, and it has also signaled plans to move ATI-052 into a Phase 2b program, initially in asthma, later in 2026. These updates are important because they help validate the program’s translational potential and expand the range of possible indications. ([investor.aclaristx.com](https://investor.aclaristx.com/news-releases/news-release-details/aclaris-therapeutics-reports-fourth-quarter-and-full-year-2025))
A second major program is ATI-2138, an oral dual inhibitor of ITK and JAK3. Aclaris has recently identified lichen planus as the lead indication for this asset and intends to launch a phased basket study covering the most common lichen planus subtypes, including erosive mucosal, cutaneous, and lichen planopilaris. The company argues that the opportunity in lichen planus is meaningful because there are currently no FDA-approved therapies, underscoring the unmet medical need. Aclaris is also evaluating additional inflammatory and alopecia-related indications linked to this mechanism of action. ([investor.aclaristx.com](https://investor.aclaristx.com/news-releases/news-release-details/aclaris-therapeutics-announces-positive-full-top-line-first))
Competitive positioning is centered on differentiation rather than scale. Aclaris does not compete as a commercial dermatology platform with large marketed revenues; instead, it competes as a focused clinical-stage innovator aiming at under-served immune-inflammatory diseases. Its geographic footprint is primarily U.S.-based, with operations centered in Pennsylvania and select collaborations or licensing arrangements abroad. The latest corporate update reported cash, cash equivalents and marketable securities of $151.4 million at December 31, 2025 and stated that this should fund operations into the second half of 2028, excluding certain future trial costs and business development activity. ([investor.aclaristx.com](https://investor.aclaristx.com/news-releases/news-release-details/aclaris-therapeutics-reports-fourth-quarter-and-full-year-2025))
Recent corporate milestones include the February 2026 year-end results release, ongoing Phase 1b enrollment for ATI-052 in both atopic dermatitis and asthma, and the company’s continued expansion of its immunology pipeline. For investors in France, Belgium, and Switzerland, Aclaris is therefore a classic NASDAQ biotech story: scientifically interesting, clinically driven, and highly sensitive to readouts, partnering decisions, and funding visibility. ([investor.aclaristx.com](https://investor.aclaristx.com/news-releases/news-release-details/aclaris-therapeutics-reports-fourth-quarter-and-full-year-2025))
| Fiscal year end | Revenue | Net income | Diluted EPS | Filing |
|---|---|---|---|---|
| Dec 2025 | 7.8 m USD | -64.9 m USD | -0.53 USD | 10-K |
| Dec 2024 | 18.7 m USD | -132.1 m USD | -1.71 USD | 10-K |
| Dec 2023 | 31.2 m USD | -88.5 m USD | -1.27 USD | 10-K |
| Dec 2022 | 29.8 m USD | -86.9 m USD | -1.33 USD | 10-K |
| Dec 2021 | 6.8 m USD | -90.9 m USD | -1.60 USD | 10-K |
Amounts in USD, as filed (forms 10-K, 20-F or 40-F). Source: SEC EDGAR.